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Associated Data
Biebel O, Bieniek SP, Biglietti M, Bilbao De Mendizabal J, Bilokon H, Bindi M, Bronner J, Brooijmans G, Brooks T, Brooks WK, Brosamer J, Brost E, Stephans GS, Sumorok K, Varma M, Velicanu D, Veverka J, Wang J.
Description:These genes encode RING-finger domain proteins that form a complex of unknown function. Here we show that the Slx5-Slx8 complex, but not its individual subunits, stimulates several human and yeast Ub conjugating enzymes, including Ubc1, 4, 5, and UbcMms2. Targets of the in vitro ubiquitination reaction include the Slx5 and Slx8 subunits themselves, and the homologous recombination proteins Rad52 and Rad We propose that the Slx5-Slx8 complex functions as a two-component Ub ligase in vivo and that it controls genome stability and sumoylation via ubiquitination.
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